LD₅₀ & Acute Toxicity Class
Look up acute toxicity for a common laboratory or industrial chemical: oral and dermal LD₅₀, inhalation LC₅₀, and the GHS acute-toxicity category that drives SDS Section 11, hazard statements, and waste routing. This is a reference lookup, not a dose-response calculator.
How to use this tool
Look up how acutely toxic a chemical is, the LD₅₀/LC₅₀ figures and the GHS acute-oral category that drives SDS labelling. It's a reference lookup, not a dose-response calculator.
What to enter
- Name or CAS number: part of a name (e.g. chlor) or a full CAS number (e.g. 67-64-1). The quick-pick pills under In the dataset load the curated built-in set.
Reading the result
The headline is the oral LD₅₀. Below it: the GHS acute-oral category (lower number = more toxic), the GHS hazard classification (signal word, pictograms, H-codes), and a table of values by route and species. The note names the data source actually used, always defer to the substance SDS, Section 11.
Worked example
The default search, toluene, returns its oral and dermal LD₅₀, inhalation LC₅₀ and the GHS acute-oral category derived from the oral LD₅₀.
Find a chemical
Result
Methodology
The GHS acute oral toxicity category is assigned from the oral LD₅₀ (mg/kg body weight) using the UN GHS cut-offs: Category 1 ≤ 5, Category 2 ≤ 50, Category 3 ≤ 300, Category 4 ≤ 2000, Category 5 ≤ 5000; above 5000 is not classified for acute oral toxicity. Lower category number means more toxic.
Sources & limits
- Live data is layered over a built-in set: authoritative acute LD₅₀ from the US EPA CompTox (CCTE ToxValDB) where configured, then PubChem ChemIDplus (RTECS), falling back to representative ECHA C&L / GESTIS figures built into the page. The result note names the source actually used.
- GHS hazard classification (signal word, pictograms, H-codes) is read live from PubChem via a same-origin proxy; it unions all aggregation groups, so more codes may appear than in any single notifier's classification.
- Reported values vary between studies, species, and routes. The displayed category reflects the oral route; a substance's harmonised SDS classification may be driven by a different route or by chronic endpoints not covered here.
- Always defer to the manufacturer's SDS (Section 11) for the authoritative classification. A blank route means no reliable public single-value figure was tabulated.